Acitretin medication belong to Retinoid class. Acitretin is used in the treatment of severe psoriasis.

Acitretin when used with phototherapy, the phototherapy dose should be decreased by the prescriber based upon the patient’s individual response. Relapses may be treated as outlined for initial treatment.

How to Take Acitretin

Take Acitretin exactly as prescribed by health care provider. For inhalation or direct instillation into bronchial tree. Not for parenteral administration. Acitretin is available in form of Capsules 10 mg, Capsules 25 mg.

Contraindications of Acitretin

Pregnancy; severe liver or kidney function impairment; chronic abnormal elevation in blood lipid values; concurrent use of methotrexate or tetracyclines; hypersensitivity to other retinoids or any component of the product.

Interactions of Acitretin with other drugs

Ethanol: Concurrent use of alcohol and acitretin may lead to the formation of etretinate, which increases the duration of teratogenic potential in women. Glyburide: The glucose-lowering effect of glyburide may be potentiated. Methotrexate: Because the risk of hepatitis may be increased, concurrent use is contraindicated. Phenytoin: Protein binding of phenytoin may be reduced. Progestin “minipill”: Acitretin may interfere with the contraceptive effect. Tetracyclines: Because acitretin and tetracyclines can cause increased intracranial pressure, concurrent use is contraindicated. Vitamin A, oral retinoids: Because the risk of hypervitaminosis A is increased, concurrent use is contraindicated.

What are the Side Effects of Acitretin -

Like other medicines, Acitretin can cause side effects. Some of the more common side effects of Acitretin include

* headache, pain, depression, insomnia, somnolence (1% to 10%); myopathy with peripheral neuropathy, aggressive feelings and/or suicidal thoughts, * Alopecia, skin peeling (60% to 75%); dry skin, nail disorder, pruritus (25% to 50%); erythematous rash, hyperesthesia, paresthesia, paronychia, skin atrophy, sticky skin (10% to 25%); abnormal skin odor, abnormal hair texture, bullous eruption, cold/clammy skin, dermatitis, increased sweating, psoriasiform rash, purpura, pyogenic granuloma, rash, seborrhea, skin fissures, skin ulceration, sunburn, infection (1% to 10%); skin thinning, skin fragility and scaling . * Increased phosphorus, potassium, sodium, magnesium, decreased magnesium (10% to 25%); increased calcium, chloride, decreased calcium, chloride, phosphorus, potassium, sodium (1% to 10%). * Arthralgia, spinal hyperostosis (10% to 25%); arthritis, arthrosis, back pain, hypertonia, myalgia, osteodynia, peripheral joint hyperostosis (1% to 10%). * Increased triglycerides (50% to 75%); increased CPK, fasting blood glucose (25% to 50%); decreased fasting blood sugar, high occult blood (10 to 25%); anorexia, edema, fatigue, hot flashes, increased appetite, gingival bleeding, gingivitis, increased salivation, thirst, infection, decreased and increased iron, flushing (1% to 10%).

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